Tissue Engineered Nanofibrous Vascular Graft

Toward a patient-specific tissue engineered vascular graft

Integrating three-dimensional printing with the creation of tissue-engineered vascular grafts could provide a readily available, patient-specific, autologous tissue source that could significantly improve outcomes in newborns with congenital heart disease. Here, we present the recent case of a candidate for our tissue-engineered vascular graft clinical trial deemed ineligible due to complex ana...

The Tissue-Engineered Vascular Graft—Past, Present, and Future

Cardiovascular disease is the leading cause of death worldwide, with this trend predicted to continue for the foreseeable future. Common disorders are associated with the stenosis or occlusion of blood vessels. The preferred treatment for the long-term revascularization of occluded vessels is surgery utilizing vascular grafts, such as coronary artery bypass grafting and peripheral artery bypass...

A collagen/vascular smooth muscle cells (SMCs) incorporating elastic scaffold for tissue-engineered vascular graft

Statement of Purpose: This study was focused on a collagen/cell mixture seeding method to improve the adhesion and proliferation of vascular smooth muscle cells (SMCs) in tubular porous scaffolds for vascular grafts application. Recently, poly(L-lactide-co-εcaprolactone) (PLCL) copolymers have been applied as a biomaterial for vascular graft due to the high elastic property. We previously repor...

Neotissue Remodeling of Tissue-engineered Arterial Graft

Tissue-Engineered Vascular Graft of Small Diameter Based on Electrospun Polylactide Microfibers

Tubular vascular grafts 1.1 mm in diameter based on poly(L-lactide) microfibers were obtained by electrospinning. X-ray diffraction and scanning electron microscopy data demonstrated that the samples treated at T = 70°C for 1 h in the fixed state on a cylindrical mandrel possessed dense fibrous structure; their degree of crystallinity was approximately 44%. Strength and deformation stability of...